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Topical application uses concentrations between 0.005 and 0.1 percent in a cream base, applied twice daily to affected areas

142 Activity-dependent mRNA translation and protein synthesis Several activity-regulated translational control pathways have been demonstrated to participate in pathologies of autism, such as the ERK/MAPK (mitogen-activated protein kinase) 143 and PI3K/mTOR (mammalian target of rapamycin) pathways

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