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For example, studies of healthy females found that the low level of serum folate in 677TT genotype is associated with an increase in homocysteine concentration and DNA hypomethylation 91,92 , which reveals the association between MTHFR C677T polymorphisms and nutrient status

Additionally, analyzing the contents of cancer EVs found in body fluids may enable their use as clinically valuable diagnostic and prognostic biomarkers, as well as potential therapeutic targets (Urabe et al., 2020)