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This pH gradient provides an ideal environment for targeted drug delivery by pH-sensitive hydrogels, such as phenylboronic acid (PBA)-modified dendrimers, enabling them to dissociate and release alkaline drugs (e.g., insulin-like growth factor-1) in acidic conditions

[DOI] [PMC free article] [PubMed] [Google Scholar] 285.Gubert C., Kong G., Costello C., Adams C.D., Masson B.A., Qin W., Choo J., Narayana V.K., Rogers G., Renoir T., et al

However, these mechanisms are only part of the factors that affect skin tone

Colman H, Mott F, Spira AI, Johnson TS, Zakharia Y, Vahanian NN et al