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As a last line of defense, when all attempts to prevent PC fail, cells direct carbonylated proteins for degradation to reduce the accumulation of dysfunctional and misfolded proteins (80, 135137)

For a brain suffering from an acute metabolic crisis, this delay is catastrophic

The mechanism to produce it at cervical spinal cord is unknown but usually self-limited despite in some exceptional cases it could appear lately and be persistent during months [10, 11]

For instance, miRNAs associated with chemotherapy resistance, such as miR-23a-3p and miR-181c-5p, have been found to influence patient prognosis (82)

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