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The effects of ER stress on the advanced plaque in macrophages are further demonstrated in AS-prone mice lacking CHOP, which shows blockage of macrophage apoptosis and inhibition of necrotic core formation (107, 109, 110)

Importantly, the slower labeling of both glucose and lactate pools in neurons may indicate a reduced rate of glucose uptake, which might account for delays in the labeling of intermediates in the TCA cycle

doi: 10.1016/j.molmed.2011.07.010 119 KhanSWangCH

Pharmacological agents or genetic approaches that modulate the activities of SOD and CAT enzymes are being considered as potential therapeutic targets

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