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First, S100A8/S100A9 promotes tumor cell growth through the activation of the NF-B signaling pathway in a RAGE-dependent manner (126), while S100A8/S100A9 can interact with RAGE (127)

Disclosures: Daniel Yan Zheng Lim: Nothing to Disclose, Siyuan Yin: Nothing to Disclose, Charlene Tan Hui Ru: Nothing to Disclose, Jeanette Ng: Nothing to Disclose, Chee-Kiat Tan: Eisai: Advisor, Abbott Laboratories: Advisor, Gilead Sciences: Advisor, Roche Diagnostics: Advisor, Fujifilm: Advisor, George Boon Bee Goh: Nothing to Disclose 2066 MULTIPLEXED IN VIVO SCREENING REVEALS THE DELETERIOUS EFFECTS OF FIBROGENIC FACTORS ON HEPATOCYTES Joanne Hsieh 1 Vinay Kartha 1 Hikaru Miyazaki 1 Christopher Carrico 1 Linda Chio 1 Daniel Fuentes 1 Dimitry Popov 1 Ian Driver 1 Chris Towne 1 Francisco LePort 1 Martin Borch Jensen 1 , 1 Gordian Biotechnology Background: Hepatocyte injury and death promotes fibrosis deposition, but the ramifications of extracellular matrix composition on hepatocytes is less understood

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Funding This work did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors