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ClinicalTrials.gov identifier: NCT03275285

S4d and S5b), and rice plants overexpressing OsVIRK1 6A -GFP did not show increased resistance to RSV infection (Supplementary Fig

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In the other Phase I/IIa clinical study, co-administration of HTI with a single bNAb targeting the Env V3 loop (101074) and the LRA RMD was evaluated (ClinicalTrials.gov Identifier: NCT03619278).17 The 101074 Ab is a potent anti-HIV-1 neutralizing antibody that binds to the V3 glycan on the gp120.75 It is hypothesized that LRA can induce Env expression on the surface of latently infected cells, and make them an accessible target for broadly neutralizing antibodies.76 Thus, the safety, immunogenicity and effectiveness of the combined HTI+Ab+LRA vaccination were evaluated in participants who were randomized into 4 study arms