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Dysbiosis Imbalances in the microbiome may promote metabolic disturbances through altered microbial metabolism and inflammatory signaling

Moreover, NEDD4 knockdown in HK-2 cells was adequate to inhibit the ubiquitination of PPAR (Fig

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In addition to pyruvate-derived acetyl-CoA, -KG-derived metabolites (e.g., succinate and fumarate) generated via glutaminolysis are considered oncometabolites contributing to tumorigenesis 23