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Expert Opinion on Biological Therapy (2012) 11

Bristol Myers Squibb (2025)

This stage 3 of COVID-19, when the disease may rapidly progress to fatality, has been continuously elucidated and referred to as cytokine storm, given the presence of elevated levels of inflammatory cytokines and chemokines including interleukin 1 (IL-1), IL-6, tumor necrosis factor (TNF), granulocyte-macrophage colony-stimulating factor (GM-CSF), gamma interferon, and monocyte chemotactic protein-1 (MCP-1)