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By mid-2025, three PROTACs, vepdegestrant (ARV-471), catadegbrutinib (BGB-16673), and gridegalutamide (BMS-986365), had advanced to Phase 3 in the United States

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From these findings, the authors suggested that the formulation may be an attractive approach for nose-to-brain delivery of donepezil, providing advances in the AD treatment

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This hypothesis is centered on the idea that the accumulation of A peptides derived from amyloid precursor protein (APP) plays a major role in disease development