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2.6 H&E and AB-PAS staining Paraffin-embedded colonic tissue blocks were cut into 4-m-thick sections for H&E staining (Duan et al., 2023)

83 CD40 is primarily expressed in B cells, and upon binding to CD40L on the surface of activated T cells, one pathway activates non-canonical NF-B signaling through the recruitment of TRAF2 and TRAF3, and the other pathway participates in canonical NF-B signaling through the recruitment of TRAF6

Schematic illustration of the core biological pathways

But it is unprecedented for a drug to be put on the pathway to widespread adoption in this manner instead of having to go through the more arduous and evidence-based FDA drug approval process, experts say

This doesn't mean you have to pick a favorite and ditch the rest