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Exploratory research on peptideprotein interactions in cell and tissue preparations

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Mice exposed to chronic unpredictable mild stress (CUMS) for 6 weeks showed increased hypothalamic corticotropin-releasing hormone concentrations, elevated corticosterone levels and increased blood ammonia, which corresponded with anxiety-like behaviors, demonstrating HPA axis involvement in anxiety pathogenesis (Jia et al., 2024)

Jia et al

To test this, we measured binding of complement factors following capture of equal titrated amounts of the NIP IgG1 antibodies on NIP-conjugated bovine serum albumin (BSA) coated in ELISA wells, which revealed considerably enhanced C1q binding (Fig