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Influence of sleep deprivation and circadian misalignment on cortisol, inflammatory markers, and cytokine balance

FIGURE 1 Mitochondrial Dynamics Mitochondria are highly dynamic and mobile organelles, constantly undergoing membrane remodeling through fission, fusion, and turnover to maintain mitochondrial homeostasis and function

The first involves binding with the Toll-Like Receptors (TLR) complex, which activates nuclear factor B and leads to the production of pro-inflammatory cytokines, including IL-1 and TNF-, as well as reactive oxygen species (ROS) and reactive nitrogen species (RNS)