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In contrast, for elements at the higher affinity end of the Irving-Williams series the binding affinities are such that there is no free (hydrated) metal present, and protein metalation involves ligand-exchange reactions between small molecule ligands or protein chaperones and nascent metalloproteins (Foster et al., 2022)

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Sikiric P, Seiwetht S, Ruckman R, Brain-gut Axis and Pentadecapeptide BPC 157: Theoretical and Practical Implication

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