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Model performance was demonstrated by comparison of predicted to observed plasma concentration-time profiles in Supplementary Figures S1S7, and predicted to observed AUC and C max values was presented in Supplementary Table S3

Mice were given ML385 (30 mg/kg, ip, qd) for 7 d

Epigenetic and metabolic reprogramming of monocytes and macrophages constitute the mechanistic underpinnings of trained immunity, bolstering mycobacterial eradication and fostering expeditious clearance (235)