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2018 Feb 1;114(2):300-311

Naunyn Schmiedebergs Arch Pharmacol 397(11):81658188

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Particularly noteworthy is CKDs propensity to transcend the boundaries of isolated renal dysfunction, precipitating a constellation of cardiovascular complications and metabolic derangements that collectively contribute to substantially elevated all-cause mortality, thereby underscoring the imperative for innovative therapeutic paradigms