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45 Research from our department and other labs suggests that perturbations of a complex equilibrium between monomers and multimers, as well as between free and membrane-bound states, may represent an initial biochemical change that eventually leads to S- and membrane-rich cytoplasmic inclusions (LBs/neurites) and progressive neurotoxicity

DSouza MS, Labrague LJ, Karkada SN, Kamble P

So, it would be preferable to start it as a pediatric medication, but those are more difficult to get approval for, Penzes said

Human cortical neurogenesis is altered via glucocorticoid-mediated regulation of ZBTB16 expression

ALT Alanine aminotransferase (previously called SGPT or serum glutamic pyruvic transaminase)