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In this study, all participants had normal health status and blood pressure levels, a fact that may help explain why no substantial treatment effect was evident

In a study where recreationally active participants ingested 3.4 g of Cit per day from watermelon juice for 16 days, there was a significant increase in plasma nitrite and plasma Arg [73]

The mechanisms by which certain medications bring about oral mucosal melanin hyperpigmentation include upregulation of tyrosinase activity, deposition of complexes of the drug with pre-existing melanin in the mucosa, or induction of local inflammatory reactions with the triggering of melanin production [11, 38]

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