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The GM can further regulate serotonin availability by signaling enterochromaffin cells to produce serotonin via expression of tryptophan hydroxylase, and by altering levels of SCFAs and BAs which can influence serotonin production (46, 164, 221223)

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Therefore, the assessment of mitochondrial transfer signatures holds potential value for predicting therapeutic resistance and guiding clinical decision-making in immuno-oncology