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Ferroptosis in tumor therapy Targeted cell death is a common approach in tumor therapy [143]

OVA elicited ROS overproduction in IECs

In addition, increased p53 expression inhibits the expression of the system xc SLC7A11, resulting in reduced uptake of cystine, decreased GSH peroxidase activity, reduced cell antioxidant capacity, and increased sensitivity of cells to ferroptosis (Kang et al., 2019)