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Akt/mTOR is active in approximately 67% individuals with EGFR mutations (Sanaei et al., 2022)

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AP: Methodology, Resources, Writing original draft, Writing review & editing, Investigation

In HCC patients, canonical TAM subsets (e.g., SPP1 + TAMs) promote tumor progression through the secretion of factors including macrophage migration inhibitory factor (MIF) and secreted phosphoprotein 1 (SPP1/osteopontin)