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The response to DNA damage, including DNA double-strand breaks, single-strand breaks, and base damage, activates the ATM/ATR/Chk1 kinase pathway, leading to upregulated PD-L1 expression in cancer cells

Thus, in order to control the progression of DM complications, it is important to control hyperglycemia [24]

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For metabolite extraction, 5 l of urine was transferred to a glass insert and extracted using 195 l of cold 80% methanol spiked with 500 nM metabolomics amino acid standard mix (Cambridge Isotopes Laboratory)

doi: 10.1097/MNH.0000000000000160