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The requirement of two distinct glutathione interaction sites for the efficient reduction of GSSR by GSH explains the deviating properties and substrate preferences of glutaredoxin subfamilies as well as thioredoxins with implications for the design and optimization of artificial enzymes and inhibitors

Travaglini P, Ambrosi B, Beck-Pecoz P, Elli R, Rodena M, Trotto G

Catalase and Neurodegenerative Diseases Alzheimers disease (AD) is characterized by the accumulation of amyloid- (A), neurofibrillary tangles, cognitive decline, mitochondrial dysfunction, and oxidative stress-induced damage

doi: 10.3390/cells8091055 58 ZhaoD.FukuyamaS.Sakai-TagawaY.TakashitaE.ShoemakerJ

It was shown that HB acts in vitro as a neuroprotective agent against the toxicity of MPTP, which induces a defect in the mitochondrial complex I of dopaminergic neurons (157)