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Not surprisingly, a number of Dot/Icm effectors known to be involved in ubiquitin signaling were identified

A vestibular migraine affects the balance and coordination systems, which can result in dizziness, vertigo, and difficulty with balance

Taken together, these observations point to a future therapeutic paradigm that is inherently combinatorial: mitigation of metabolic and inflammatory stressors, protection and regeneration of endogenous -cells, and, where necessary, -cell replacement, complemented by targeted modulation of the gut microbiota