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That so many disease-causing lysosomal genes converge directly on pH regulation within this vital organelle is remarkable, and novel evidence continues to emerge

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Mice were anesthetized separately using 2% isoflurane and an incision was made in the middle of the abdomen, prior to samples (blood and liver tissue) being collected for further analysis

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Interestingly, we also show that kynurenine, a metabolite derived from tryptophan following inflammatory activation of IDO1 [46,47,48], is elevated in TTR-V30M patients but not in age-matched healthy controls