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However, in vivo use of free RES is limited by poor stability and low bioavailability

20,104,105,106,107,108 GHR dysfunction clearly protects individuals with Laron Syndrome against aging-related diseases such as cancer and diabetes, but it is unclear whether GH/IGF1 deficiency increases human lifespan, although a handful of studies have indicated that attenuated GH/IGF1 function is associated with human longevity

A Complete Response Letter (CRL) from the FDA, essentially a request for more information or additional studies, would add at least 12 months to the timeline

The results shown are representative of three independent experiments

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