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Four mechanisms are established by over 500 peer-reviewed publications from the Zagreb school (Sikiric, Seiwerth, Staresinic, Krivic) and independent laboratories: 1

Inhibitors of eryptosis could potentially be exploited for therapeutic purposes, particularly in conditions where excessive or insufficient erythrocyte removal contributes to disease progression [134]

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This allows it to reach tissues that wouldnt normally get much ALA which may explain why higher supplemental doses (like 600mg) can affect nerve health, blood sugar, and oxidative stress in ways your bodys natural supply cant.12 Once you take ALA as a supplement, several factors affect how well your body absorbs and uses it

doi: 10.1093/jnci/djp037 161 KyungSLimJWKimH