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208 An open crossover trial in 22 subjects with fibromyalgia found 200 mg of CoQ10 (as ubiquinone) twice daily (in a supplement that also contained vitamins B2, B6, B9, B12, and E) for three months reduced pain, fatigue, and sleep disturbance compared with no treatment

Interactions with other medications have not been systematically characterized potential interactions with CNS depressants (alcohol, sedatives, anxiolytics), opioids, or other psychoactive substances should be considered, though documented problematic interactions are not prominent in available literature

113 OsukaS.SampetreanO.ShimizuT.SagaI.OnishiN.SugiharaE.et al (2013)

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How Often Should You Have Vitamin B12 Injections