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Leptin drives fibrosis starting different intracellular pathways downstream of the long receptor isoform Ob-Rb, including Janus kinase/signal transducer and activator of transcription (JAK)/STAT pathways [161], as well as ERK and AKT-dependent pathways, which activate HSCs proliferation [162]

Notably, transplantation of fecal matter from normal mice into HU mice ameliorated the damage inflicted upon the intestinal barrier

MRI showed increased brain volumes together with improved functional connectivity, increased cerebral perfusion, and improvements in neuropsychological test scores [54]

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Combination therapy with multiple epigenetic drugs demonstrates therapeutic promise: DNMTi-induced DNA demethylation fails to reactivate tumor suppressor genes due to persistent PRC2-mediated repression