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Transfer of methyl groups by methyltransferases Methylation of the neurotransmitter histamine using S -adenosylmethionine as the methyl donor is catalyzed by histamine- N -methyltransferase (HMT, EC 2.1.1.43, Figure 7G )

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10.1016/j.jep.2015.03.066 190 WangY.WangM.FanK.LiT.YanT.WuB.et al (2018)

Instead, it appears to influence multiple brain systems involved in sleep regulation and stress