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Indeed, owing to its ability to activate the tolerogenic pathway of tryptophan catabolism via the immunoregulatory enzyme indoleamine 2,3-dioxygenase 1 (Puccetti and Grohmann, 2007), T1 specifically potentiates immune tolerance in the lung, breaking the vicious circle that perpetuates chronic lung inflammation in response to a variety of infectious noxae (Romani et al., 2006)

N Engl J Med 367(14):13321340

I make the hypothesis that the susceptibility to PAIS depends on each individual terrain, including genetics, epigenetics, lifestyle, infectious history, and so on

2005 May 1;204(3):263-73.PMID: 15845418 Alzheimers Disease Liu H, Harrell LE, Shenvi S, Hagen T, Liu RM

68 And, a first-in-human open-label interventional study in 10 neonates showed that intranasal delivery of bone marrow-derived MSCs was safe and had no adverse side effects