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In combination, we found this approach to provide an appropriate methodology for a largescale translational project based on pathologically preserved FFPE tissue proteomes while reducing the time of active tissue handling, improving reproducibility and promoting robustness (Fig 1C, Materials and Methods section)

Riluzole, [2amino 6 (trifluoromethoxy)benzothiazole] is a drug that was approved by the FDA due to its neuroprotective properties ( In cancer, glutamate receptor overexpression is linked with the activation of different signaling pathways including PI3K/AKT/mTOR, RasMAPKERK, and MAPK/ERK, which are involved in the regulation of cell proliferation, survival leading to tumorigenesis ( 2+ signaling in the immortalized growth hormonesecreting pituitary cell line GH3 ( 2+ influx

Furthermore, the observation that visual loss is associated with an increased longitudinal risk of AD diagnosis, with a greater risk observed when visual loss occurs earlier in the lifespan [228], accentuates the potential significance of aligning the endogenous melatonin rhythm with the light-dark cycle for optimal brain health in humans

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