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Mistry, J., Bateman, A.& Finn, R

To elucidate the reliance on preceding metabolic pathways fueling the tricarboxylic acid cycle (TCA) including glycolysis, -oxidation, and glutaminolysis, cells were also treated with the mitochondrial pyruvate carrier (MPC) inhibitor UK-5099, the competitive glycolysis inhibitor 2-deoxy-D-glucose (2-DG), the carnitine palmitoyltransferase 1 (CPT1) inhibitor perhexiline, and the glutaminase (GLS) inhibitor BPTES, targeting different metabolic routes (Fig

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This compound is produced in the kidneys and liver from the amino acids - methionine and lysine

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