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For humans, self-production of B12 through the intestinal bacteria is theoretically possible, but rarely achieved for health reasons, which is why humans today depend on a dietary intake of B12 in almost all cases

PMCID: PMC8536070 Ritelli M, Chiarelli N, Dordoni C, Quinzani S, Venturini M, Maroldi R, Calzavara-Pinton P, Colombi M

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Improper handling, temperature variations, and the presence of interfering substances can affect test accuracy

Hydrogen sulfide-based therapeutics: exploiting a unique but ubiquitous gasotransmitter