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While studies as far back as 1948 have demonstrated decreases in penile curvature and plaque size from vitamin E treatment, most of these studies have not used placebo controls

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However, further analysis revealed that the effect of reducing muscle soreness was more pronounced in subjects without training experience

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(2013) Oral acetyl-L-carnitine therapy reduces fatigue in overt hepatic encephalopathy: a randomized, double-blind, placebo-controlled study, The American Journal of Clinical Nutrition, 97(4), pp