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The CU suffix denotes its association with a copper (II) ion, which the peptide binds with high affinity through the imidazole group of histidine and the amino-terminal amine

Cooper, C.E

Nevertheless, the high frequency of gastrointestinal symptoms may influence long-term adherence in routine clinical practice

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Mutations applied to the key residues Phe260 (gatekeeper), Asn240 (1 st activity controller) and Leu244 (2 nd activity controller) led to significant differences in the substrate preference of the enzyme