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Lee J, Bayarsaikhan D, Arivazhagan R, Park H, Lim B, Gwak P, Jeong GB, Lee J, Byun K, Lee B

Methotrexate modulates the expression of MMP-1 and type 1 collagen in dermal fibroblast

Concurrently, endothelial dysfunction worsens owing to increased vasoconstrictor production, increased ROS, and depletion of endothelial nitrogen oxide production (124)

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1 selective agonist increases upright blood pressure by stimulating 1 receptors in both the arteriolar and venous vascular beds, thereby reducing orthostatic hypotension