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Validation of pathways up-regulated in regions of severe emphysema In order to investigate whether the up-regulation of components of the B cell receptor signaling pathway is associated with a change in the quantity of B cells in lung tissue, we quantified the Vv of CD79A protein, a marker for B cells, in relation to Lm by immunohistochemistry (see Additional file 1 for methods)

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411 Additionally, specific probiotic strains have been identified that can restore gut microbiota balance, reduce systemic inflammation, and improve nerve conduction in diabetic models

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