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46,775 Spatial transcriptomics Hepatocyte zonation within the liver lobule reflects significant functional variations driven by gradients of oxygen, nutrients, hormones, and Wnt morphogens

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Furthermore, short-chain fatty acids such as butyrate produced by periodontopathic bacterial metabolism may participate in upregulating ACSL4 expression through epigenetic regulation, although the underlying mechanisms remain to be further elucidated (27)