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For example, recent studies have shown that ER stress within beta cells leads to translational errors in the reading frame of human insulin mRNA, resulting in the generation of defective polypeptides and the formation of neo-epitopes, capable of recognition by circulating T cell populations which have escaped prior thymic deletion (Kracht et al

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Maternal dietary fat during lactation shapes single nucleus transcriptomic profile of postnatal offspring hypothalamus in a sexually dimorphic manner in mice