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A SINGLE-CENTER ANALYSIS Constance Mobley 1 Andrea Meinders 1 Elizabeth Brombosz 1 Enshuo Hsu 2 Mozhgon Moaddab 1 Ashish Saharia 1 Ashton Connor 1 Mark Hobeika 1 Caroline Simon 1 Yee Lee Cheah 1 Linda Moore 1 Victor Ankoma-Sey 3 Chukwuma Egwim 3 Tamneet Basra 1 Sudha Kodali 1 David Victor 1 Rafik Ghobrial 4 , 1 Houston Methodist Hospital, 2 University of Texas MD Anderson Cancer Center, 3 Liver Associates of Texas, 4 Houston Methodist JC Walter Transplant Center Background: Short- term mortality for patients with acute-on-chronic liver failure (ACLF) is high, around 90% at 3 months

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Current therapeutic strategies aim to decrease absorption or enhance elimination and mainly include forced diuresis, blood purification, and supportive care (Li et al

These pathways are often misregulated in specific tumours (Giordano and Tommonaro, 2019

The resulting cellular damage and death can further exacerbate skin inflammation and impair the skins barrier function, as seen in conditions like toxic epidermal necrolysis and bullous pemphigoid