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Beyond merely correcting metabolic acidosis, this approach also restricts lactate-driven histone lactylation, which influences the epigenetic regulation of TFRC expression and ferroptosis susceptibility (73,192)

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The C-terminal termination also has Ca 2+ binding sites but seems more associated with voltage-dependent responses (Sura et al., 2012)

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However, individual peptide-based medications and therapies have received FDA approval