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Additionally, ubiquitination plays various crucial roles within the cell, extending beyond protein degradation to encompass signal transduction [84], DNA repair [85], cell cycle regulation [78, 79], and the modulation of protein localization and activity [86], among other biological processes

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After 72 h, the cell culture supernatant was transferred onto freshly seeded cells and cells were lysed to analyse replication as described previously 38

Donor rights, genetic safety, clinical integrity, and equitable access need to be considered