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Whether such ectopic influences operate through the same signaling pathways as those observed within the primary cells, or involve distinct and as yet uncharacterized mechanisms, is still uncertain

Human frataxin activates FeS cluster biosynthesis by facilitating sulfur transfer chemistry

An elevated level of macroautophagy has been noted during the advancement of MSA, hinting at a potential involvement in eliminating protein clumps [314]

Mice with a deficiency of key components in the NF-B pathway die as a result of massive hepatocyte apoptosis induced by TNF 37,38 , supporting the critical role of maintenance of hepatocyte NF-B pathway in protecting against TNF cytotoxicity