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The mechanism relies on enhancing carnitine-dependent fatty acid oxidation and methyl-donor metabolism, though clinical evidence for weight loss is limited to small studies and anecdotal reports

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Dokmeci D, Akpolat M, Aydogdu N, Uzal C, Doganay L, Turan F

In that 2-arm study, the patients were divided into the group receiving Zn supplementation and standard therapy (branched-chain amino acids and lactulose) and the group receiving only standard therapy

A genetic predisposition may exist in Melkersson- Rosenthal syndrome: siblings have been affected, and otherwise unaffected relatives may have a fissured tongue (lingua plicata)