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Future research should focus on developing non-invasive or minimally invasive sampling methods to improve sample diversity and conduct large multicenter cohort studies to enhance result generalizability

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Their potencies against LXR and LXR were evaluated in biochemical binding assays, cellular mammalian two-hybrid interaction assays evaluating nuclear receptor co-repressor (NCOR) recruitment and cellular reporter assays evaluating transcriptional activity (Fig

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Additional information Peer review information Nature Communications thanks Maggie Levy and Philippe Simoneau for their contribution to the peer review of this work