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In rare cases where B12 is essential but acne remains intractable, dermatologists may consider oral isotretinoin, which in the UK can only be initiated by consultant dermatologists and requires strict monitoring, including a pregnancy prevention programme for women of childbearing potential

Rodent osteoarthritis models (surgically induced) showed improved histological cartilage scores with AOD-9604 treatment versus vehicle control

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Aside from that, B12 has anti-inflammatory properties that reduce swelling around the wound