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Wijesooriya K, Weiss E, Dill V, Dong L, Mohan R , Joshi S, Keall PJ

HTRA1 interacts with SLC7A11 to modulate colorectal cancer chemosensitivity by inhibiting ferroptosis

ROS inducers can promote the formation of lipid rafts on the plasma membrane, which contain important molecules involved in TCR signaling, such as LAT, PLC1, and PKC (125) ( Figure 2 )

The authors linked the cyanide mode of action to the ROS level in the functional mitochondria and the hypoxia-inducible factor-1 alpha (HIF-1) signalling pathway

At the same time, sirtuin 1 (SIRT1) and SIRT3 deacetylate PGC-1, increasing its interaction with transcription factors and enhancing its coactivator function under conditions of caloric restriction or redox stress ( Once activated, PGC-1 translocates to the nucleus and forms functional complexes with nuclear respiratory factors, primarily NRF1 and NRF2