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Eisai and Biogen said in a release that they plan to apply for U.S

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In addition, any factors that impair blood flow to the local tissue will affect the rate and extent of drug absorption

Researchers suggest that elevated gut pH, gut dysbiosis (i.e., a higher Firmicutes : Bacteroidetes ratio), obesity, or malabsorption might increase fecal SCFA, such as butyrate, which could have potential neurotoxic effects [25, 45, 46]