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Cao W, Chen H-D, Yu Y-W, Li N, Chen W-Q

Lampley, E

These metabolic disturbances activate several pathogenic pathways that contribute to neuronal dysfunction and death, ultimately manifesting as DPN

Emerging evidence suggests that inflammatory stimuli [7], dysregulation of the ubiquitin-proteasome system [8], and disturbances in immune modulation [9] play key roles in its development